Psilocybin Spurs Growth of Neural Connections Lost in Depression

Psilocybin Spurs Growth of Neural Connections Lost in Depression

In a groundbreaking study published in the journal Neuron, researchers from Yale University have discovered that a single dose of psilocybin can stimulate an immediate and long-lasting increase in neural connections in the brain.

This finding holds promise for the treatment of depression, a condition marked by a reduction in neuronal connections.

It also sheds light on how psilocybin produces its therapeutic effects and provides new insights into the neurobiology of depression.

Psilocybin study

Psilocybin, a naturally occurring compound present in psychedelic mushrooms, has attracted significant attention in recent years as a potential treatment for depression.

However, the precise mechanisms through which psilocybin exerts its therapeutic effects and the duration of its benefits have remained unclear.

In this recent study, researchers at Yale University aimed to elucidate the impact of psilocybin on neural connections and shed light on its potential as a treatment for depression.

Strengthening connections in the brain

The Yale research team administered a single dose of psilocybin to mice and observed a remarkable increase in the number and strength of neuronal connections.

Using a high-resolution laser-scanning microscope, the scientists imaged dendritic spines, small protrusions on nerve cells responsible for information transmission, in living mice over multiple days.

Within 24 hours of psilocybin administration, there was a significant increase in both the number and size of dendritic spines, indicating enhanced neural connectivity. Importantly, these changes persisted even a month after the treatment.

Promising results for stress-induced depression

The study also revealed that psilocybin administration led to behavioural improvements and increased neurotransmitter activity in mice subjected to stress, a known trigger for depression.

This suggests that psilocybin has the potential to counteract the detrimental effects of chronic stress on neuronal connections, offering much hope for individuals suffering from stress-induced depression.

Exploring the mystical experience

Psilocybin has long been associated with inducing profound mystical experiences, both in traditional religious ceremonies and recreational use.

The researchers speculate that the unique psychological effects of psilocybin may be responsible for stimulating the growth of neural connections.

According to Alex Kwan, the senior author of the study and an associate professor at Yale, the enduring changes observed after a single dose of psilocybin could represent the brain's structural adaptations to store new experiences.

Implications for depression treatment

Depression is characterised by a decrease in neural connectivity, and this study provides valuable insights into potential therapeutic interventions.

The ability of psilocybin to enhance neural connections offers a new avenue for the development of treatments for depression that target the underlying neurobiology of the disorder.

However, further research is needed to understand the specific mechanisms through which psilocybin influences neural connectivity and to evaluate its long-term effects.


The study conducted by Yale University researchers highlights the remarkable effects of a single dose of psilocybin on the growth of neural connections in the brain.

By demonstrating the immediate and long-lasting increase in dendritic spines, this study provides compelling evidence of the therapeutic potential of psilocybin for depression.

These findings open new doors for exploring the use of psychedelics in mental health treatments and emphasise the importance of continued research in this field.


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