There’s little better than cradling a warm cup of coffee, that comforting smell swirling around you as a splash of milk turns your brew into a creamy indulgence.
What if I told you that this simple pleasure might actually be the key to reducing inflammation in your body and brain?
Sounds too good to be true? Science says otherwise.
The Unexpected Healing Power of Your Morning Brew
New research from the University of Copenhagen has uncovered something fascinating—combining proteins with polyphenols (the antioxidants found in plants, fruits, vegetables, and fungi) could double the anti-inflammatory effects in immune cells.
That’s right, your humble coffee-milk combo isn’t just a pick-me-up—it could be a powerful health-boosting tool.
We often think of inflammation as the villain in the story of health. But it’s actually your body’s natural response when fighting off invaders like bacteria and viruses.
But chronic inflammation? That’s a different beast—linked to conditions like rheumatoid arthritis, heart disease, and even cancer.
Enter polyphenols: nature’s microscopic warriors found in everything from coffee beans and mushrooms to red wine and dark chocolate.
These compounds help combat oxidative stress, a key contributor to inflammation. And when these polyphenols meet proteins, their superpowers seem to amplify.

Coffee + Milk = Inflammation Gone
In the Copenhagen study, researchers explored what happens when polyphenols react with amino acids (the building blocks of proteins).
They simulated inflammation in immune cells and then introduced different treatments:
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Cells treated with pure polyphenols.
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Cells treated with polyphenols combined with amino acids.
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A control group that received nothing.
The results?
The cells exposed to the polyphenol-protein combo were twice as effective at fighting inflammation compared to those that only received polyphenols.
That’s a serious improvement.
Another study, this time from 2022, found when mice were given milk combined with the coffee-polyphenol chlorogenic acid:
🔬 It prevented death: In experimental models, half of the control group didn’t make it. But those getting the coffee-and-milk magic? Zero deaths. None. Nada.
🧠 Improved memory: Participants showed clear improvements in memory, meaning that brain fog might just meet its match in your morning latte.
🔥 Lowered inflammation: This combo drastically reduced neuroinflammation—specifically targeting markers like TNFα and IL-1β, which are key drivers of brain ageing and cognitive decline.
There are now a series of studies showing that milk is a highly effective drug-delivery vehicle, particularly for water soluble compounds.
Tradition Meets Science
Here’s the thing: cultures around the world have been blending coffee with milk for centuries.
From Italy’s cappuccinos to India’s creamy spiced coffee, tradition had it right all along.
Now, modern research proves what your taste buds always knew—this combo isn’t just delicious, it’s deeply beneficial.
Other sources of polyphenols
Turns out, the powerful reaction between polyphenols and amino acids happens naturally in coffee with milk.
Coffee beans are loaded with polyphenols, and milk is rich in proteins. So, when combined, these two create a molecular match made in heaven.
But this reaction isn’t exclusive to milk and coffee—it could happen anytime you mix protein-rich foods with polyphenol-packed ingredients.
Think:
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A smoothie with berries and Greek yogurt
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A hearty meat dish paired with a side of cooked vegetables
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Even a glass of red wine alongside a cheese platter (yes please!)
The Mushroom Connection: A Polyphenol Powerhouse
Let’s not forget mushrooms.
Fungal fruiting bodies (mushrooms) are rich in unique bioactive polyphenols.
Studies have shown that polyphenolic compounds from mushrooms can help prevent chronic diseases by enhancing antioxidant defences, promoting cellular health, and blocking inflammation.

For those deep into biohacking, this adds another layer of depth: imagine a coffee infused with functional mushroom extracts and pairs perfectly with milk.
A triple-threat beverage that sharpens focus, boosts immunity, and reduces inflammation?
Say hello to Mushies' Super Mushroom Nootropic Coffee.
This isn’t your average brew—it's packed with powerful polyphenols from high-quality coffee beans, functional mushroom extracts, and a collection of other powerful adaptogen herbs known for their brain-boosting, health-enhancing properties.
Try it with a splash of milk.
Not only will you get that smooth, creamy texture, but you’ll also unlock the full anti-inflammatory potential by combining polyphenols and proteins.
Final sip
So tomorrow morning, when you’re pouring that splash of milk into your coffee, don’t just think of it as a flavour enhancer—think of it as an anti-inflammatory, brain-nourishing gift.
A simple, delicious, scientifically-backed ritual that could help you think clearer, live longer, and age smarter.
And if you want to take things a step further?
Toss in some functional mushrooms for a powerful, inflammation-fighting brew.
Or try ours here.
In the world of nutrition science, it’s often the simplest things—like that morning cup of coffee—that hide powerful secrets.
Here’s to milky mushroom coffee!