Who Shouldn’t Take Lion’s Mane?

Who Shouldn’t Take Lion’s Mane?

Lion's mane mushroom has gained considerable attention in recent years as a natural supplement with profound brain-boosting and neuroprotective properties. 

However, before you jump on the lion's mane bandwagon, it's crucial to understand that this fungi isn't a one-size-fits-all solution.

While lion's mane boasts a remarkable range of potential benefits, its effects and safety profile can vary from person to person. 

In this blog post, we delve into the important considerations surrounding lion's mane usage and explore who might want to exercise caution or even avoid it altogether. 

What is lion’s mane?

Lion's mane, scientifically known as Hericium erinaceus, is a type of mushroom with a distinctive appearance resembling a lion's mane, hence its name.

This unique mushroom has a long history in traditional Chinese and Japanese medicine, where it was valued for its brain and gut health benefits. 

Lion's mane is typically found growing on hardwood trees in North America, Europe, and Asia. It is often used in culinary dishes, prized for its delicate flavour and lobster-like texture.

How does lion’s mane work?

Researchers have become increasingly interested in lion’s mane due to its ability to support brain health and cognitive function.

You see, lion's mane contains bioactive compounds, such as hericenones and erinacines, that have been shown to stimulate the production of nerve growth factor (NGF), a protein essential for the growth, maintenance, and repair of neurons (brain cells).

In addition to its cognitive benefits, lion's mane also offers immune system support and anti-inflammatory properties. 

What’s lion’s mane good for?

While research on this remarkable fungus is ongoing, here are some of the areas where lion's mane has shown promise:

  • Cognitive function: Lion's mane is most celebrated for its potential cognitive benefits. It contains compounds that stimulate the production of nerve growth factor (NGF). NGF plays a crucial role in the growth, maintenance, and repair of neurons, which can have a positive impact on memory, focus, and overall cognitive function. 
  • Neuroprotection: Some studies suggest that lion's mane may have the potential to protect against neurodegenerative conditions, such as Alzheimer's and Parkinson's diseases.

  • Nervous system health: Lion's mane may have a positive impact on the central nervous system. Some research indicates that it could help with conditions like neuropathy and multiple sclerosis by promoting nerve regeneration and reducing inflammation.
  • Digestive health: Traditional Chinese and Japanese medicine have used lion's mane to support digestive health. It may help maintain a healthy gut by promoting the growth of beneficial gut bacteria, improving digestion and potentially alleviating symptoms of gastrointestinal disorders.
  • Immune support: Some studies suggest that lion's mane may have immune-boosting properties by enhancing the activity of certain immune cells and promoting overall immune function.
  • Anti-inflammatory: Lion's mane contains compounds with anti-inflammatory properties.
  • Anxiety and depression: While more research is needed, some studies indicate that lion's mane may have a role in reducing symptoms of anxiety and depression. Its impact on mood may be related to its effects on the nervous system and NGF production.
  • General well-being: Many people take lion's mane supplements as a part of their overall wellness routine. Its adaptogenic properties help the body adapt to stress, potentially enhancing overall well-being and resilience.

Who shouldn’t take lion’s mane?

While lion's mane mushroom offers a range of potential health benefits, it's not suitable for everyone. There are certain groups of people who should exercise caution or avoid Lion's Mane supplementation altogether. Here are some considerations:

- Those with allergies

Individuals with known allergies to mushrooms or fungal species should steer clear of lion's mane, as it could trigger allergic reactions.

- Those on blood-thinning medications

Lion's mane may have mild blood-thinning effects. If you are taking blood-thinning medications (anticoagulants) such as warfarin, aspirin, or heparin, consult with your healthcare provider before using lion's mane, as it could potentially increase the risk of bleeding.

- Those with scheduled surgery

If you have an upcoming surgery, it's advisable to discontinue lion's mane supplementation a few weeks before the procedure. As mentioned, lion's mane can have mild blood-thinning effects, which could complicate surgery and post-operative recovery.

- Those pregnant or breastfeeding

Limited research is available on the safety of lion's mane during pregnancy and breastfeeding. 

- Those with individual sensitivity

While rare, some individuals may experience gastrointestinal discomfort or allergic reactions even if they do not have known allergies to mushrooms. If you're new to lion's mane, start with a small dose and monitor your body's response.

Always remember that individual responses to supplements can vary, and it's important to prioritise your safety and well-being. 

What are the side effects of lion’s mane?

While side effects are not commonly reported after taking lion’s mane, when they are reported, these are the most common:

  • Upset stomach: Some people have reported experiencing stomach discomfort or even diarrhoea after taking lion's mane. 
  • Skin rash: A few users have reported developing a rash after taking lion's mane.
  • Headache: While rare, some people have reported experiencing headaches after taking lion's mane.
  • Panic attacks: A very small percentage of people who take lion’s mane experience feelings of panic and some even have full blown panic attacks. It’s not understood why this happens, but may be linked with the mushroom’s neurogenerative properties. 
  • Sleep problems and overactive mind: Some people also experience problems getting to sleep due to an overactive mind when they take lion’s mane.

It's important to note that lion’s mane side effects are uncommon, generally mild and don't last very long.

In most cases, they go away on their own within a few hours or days. If you experience any of these side effects, it's best to stop taking lion's mane and see if they go away.

What drugs does lion's mane interact with?

As mentioned above, lion's mane may have mild blood-thinning effects. 

If you are taking blood-thinning medications (anticoagulants) such as warfarin, aspirin, or heparin, consult with your healthcare provider before using lion's mane, as it could potentially increase the risk of bleeding.

Is lion’s mane safe for children?

There is limited research on the safety and efficacy of Lion's Mane mushroom (Hericium erinaceus) supplements for children. 

However, while it's essential to exercise caution when considering giving a child any supplement, lion’s mane is a popular culinary mushroom that’s been consumed in Asia for generations, with no indication it poses harm to children or anyone else. 

Here at Mushies, we have had some fantastic reviews from parents giving their children our lion’s mane capsules extracts to help with conditions such as ADHD

Can you take lion’s mane every day?

Taking lion's mane daily is generally considered safe for when used within recommended dosages. 

However, individual responses can vary, so it's wise to start with lower doses and periodically assess the need for continued supplementation. You can also consult with a healthcare provider if you have specific health concerns.


While lion's mane offers a spectrum of benefits, its effects are not uniform among all individuals. 

From allergies to medication interactions, we've outlined the precautions that should be taken. If you fall into any of the cautioned categories, it's essential to approach lion's mane with care or seek alternative options.

Ultimately, the decision to include lion's mane in your daily routine should be made with careful consideration and respect for your unique health circumstances. 

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